Jun.-Prof.in Stefanie Duvigneau
Jun.-Prof. Dr.-Ing. Stefanie Duvigneau
Department Synthesis and Control of Sustainable Bioprocesses
Current projects
Model-based multi-stage microbial process for the production of biopolymers from side streams of the regional industry (PHA4Value)
Duration: 01.01.2024 to 30.06.2027
The central objective of the project is the development of a multi-stage process for the sustainable biotechnological production of biopolymers using carbon compounds from low-cost side streams from regional industry and the application of model-based control strategies. A CO2-utilizing microalgae process is to be coupled to a heterotrophic bacterial process for the production of biodegradable biopolymers from the group of polyhydroxyalkanoates (PHAs) in order to optimally exploit the advantages of both biotechnological processes and thus achieve an increase in yield in relation to the carbon used.
The project is a joint project that we are working on together with the Anhalt University of Applied Sciences in Köthen (Prof. Carola Griehl) and the Magdeburg-Stendal University of Applied Sciences (Prof. Robert Dürr). Within the joint project, Otto von Guericke University is focusing on the model-based development of a cost-effective PHA production process and the coupling of this with the microalgae process using a metabolic process model. The resulting process model will be used to optimize and control the multi-stage process.
This text was translated with DeepL
2024
Book chapter
Improving the production of PHBV in cupriavidus necator by optimal control
Kok, Rudolph L., Johannes; Findeisen, Rolf; Kienle, Achim; Duvigneau, Stefanie
In: Computer aided chemical engineering - Amsterdam [u.a.] : Elsevier, Bd. 53 (2024), S. 2503-2508 [Symposium: 34th European Symposium on Computer Aided Process Engineering / 15th International Symposium on Process Systems Engineering, ESCAPE-34/PSE2024, Florence, Italy, 2-6 June 2024]
2023
Dissertation
Multiskalen-Modellierung der Polyhydroxyalkanoat-Biopolymer- und Influenza-A-Impfstoffproduktion
Duvigneau, Stefanie; Kienle, Achim
In: Magdeburg: Universitätsbibliothek, Dissertation Otto-von-Guericke-Universität Magdeburg, Fakultät für Elektrotechnik und Informationstechnik 2023, 1 Online-Ressource (vi, 167 Seiten, 10,89 MB) [Literaturverzeichnis: Seite 149-166][Literaturverzeichnis: Seite 149-166]
2022
Book chapter
Multiscale modeling of the microbial production of polyhydroxyalkanoates using two carbon sources
Duvigneau, Stefanie; Dürr, Robert; Wulkow, Michael; Kienle, Achim
In: Computers & chemical engineering - Amsterdam [u.a.] : Elsevier Science, Bd. 160 (2022), Artikel 107740, insges. 12 S.
2021
Book chapter
Fast, inexpensive, and reliable HPLC method to determine monomer fractions in poly(3-hydroxybutyrate-co-3-hydroxyvalerate)
Duvigneau, Stefanie; Kettner, Alexander; Carius, Lisa; Griehl, Carola; Findeisen, Rolf; Kienle, Achim
In: Applied microbiology and biotechnology - Berlin : Springer, Bd. 105 (2021), Heft 5, S. 4743-4749
Hybrid cybernetic modeling of the microbial production of polyhydroxyalkanoates using two carbon sources
Duvigneau, Stefanie; Dürr, Robert; Kranert, Lena; Wilisch-Neumann, Annette; Carius, Lisa; Findeisen, Rolf; Kienle, Achim
In: 31th European Symposium on Computer Aided Process Engineering , 2021 - Amsterdam : Elsevier ; Türkay, Metin - ESCAPE-31, S. 1969-1974 [Symposium: ESCAPE-31, Istanbul, 6-9 June 2021]
Microbial production of polyhydroxyalkanoates - modeling of chain length distribution
Dürr, Robert; Duvigneau, Stefanie; Kienle, Achim
In: 31th European Symposium on Computer Aided Process Engineering , 2021 - Amsterdam : Elsevier ; Türkay, Metin, S. 1975-1982 [Symposium: ESCAPE-31, Istanbul, 6-9 June 2021]
Advanced kinetic modeling of bio-co-polymer poly(3-hydroxybutyrate-co-3-hydroxyvalerate) production using fructose and propionate as carbon sources
Duvigneau, Stefanie; Dürr, Robert; Behrens, Jessica; Kienle, Achim
In: Processes - Basel : MDPI, Bd. 9 (2021), Heft 8, Artikel 1260, insges. 19 S.
Multi-Rate data fusion for state and parameter estimation in (Bio-)chemical process engineering
Dürr, Robert; Duvigneau, Stefanie; Seidel, Carsten; Kienle, Achim; Bück, Andreas
In: Processes - Basel : MDPI, Bd. 9 (2021), Heft 11, Artikel 1990, insges. 16 S.
2020
Book chapter
Model-based approach for predicting the impact of genetic modifications on product yield in biopharmaceutical manufacturing-Application to influenza vaccine production
Duvigneau, Stefanie; Dürr, Robert; Laske, Tanja; Bachmann, Mandy; Dostert, Melanie; Kienle, Achim
In: PLoS Computational Biology / Public Library of Science - San Francisco, Calif. : Public Library of Science - Volume 16 (2020), issue 6, article e1007810, 22 pages
Hybrid cybernetic modeling of polyhydroxyalkanoate production in cupriavidus necator using fructose and acetate as substrates
Duvigneau, Stefanie; Dürr, Robert; Carius, Lisa; Kienle, Achim
In: IFAC-PapersOnLine / Internationale Förderung für Automatische Lenkung - Frankfurt : Elsevier, Bd. 53 (2020), Heft 2, S. 16872-16877
2018
Book chapter
Mathematical modeling as a tool to improve influenza vaccine production processes
Duvigneau, Stefanie; Dürr, Robert; Laske, Tanja; Bachmann, Mandy; Dostert, Melanie; Reichl, Udo; Kienle, Achim
In: IFAC-PapersOnLine / Internationale Förderung für Automatische Lenkung - Frankfurt : Elsevier, Bd. 51 (2018), Heft 19, S. 1-4
2016
Book chapter
Analyzing the impact of heterogeneity in genetically engineered cell lines for influenza vaccine production using population balance modeling
Dürr, Robert; Duvigneau, Stefanie; Laske, Tanja; Bachmann, Mandy; Kienle, Achim
In: IFAC-PapersOnLine / Internationale Förderung für Automatische Lenkung - Frankfurt : Elsevier, Bd. 49 (2016), Heft 26, S. 225-230
Peer-reviewed journal article
An efficient approximate moment method for multi-dimensional population balance models - application to virus replication in multi-cellular systems
Dürr, Robert; Müller, Thomas; Duvigneau, Stefanie; Kienle, Achim
In: Chemical engineering science - Amsterdam [u.a.] : Elsevier Science . - 2016
Hierarchical effects of pro-inflammatory cytokines on the post-influenza susceptibility to pneumococcal coinfection
Duvigneau, Stefanie; Sharma-Chawla, Niharika; Boianelli, Alessandro; Stegemann-Koniszewski, Sabine; Nguyen, Van Kinh; Bruder, Dunja; Hernandez-Vargas, Esteban A.
In: Scientific reports - [London] : Macmillan Publishers Limited, part of Springer Nature - Bd. 6.2016, Art.-Nr. 37045, insges. 11 S.
Article in conference proceedings
Analyzing the impact of heterogeneity in genetically engineered cell lines for influenza vaccine production using population balance modeling
Dürr, Robert; Duvigneau, Stefanie; Laske, Tanja; Bachmann, Mandy; Kienle, Achim
In: FOSBE 2016 - Magdeburg ; Findeisen, Rolf - 2016, Art. TuPP.1, S. 32 [Kongress: 6th International Conference on Foundations of Systems Biology in Engineering, FOSBE 2016, Magdeburg, Germany, October 9-12,2016]
- Keine Daten im Forschungsportal hinterlegt.
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- 2009-2015 Studium Biosystemtechnik, Otto-von-Guericke Universität Magdeburg
- 2016-2023 Promotionsstudium an der Fakultät für Elektrotechnik der Otto-von-Guericke-Universität in Magdeburg
- seit 2023 Leitung des Arbeitskreises Synthese nachhaltiger biotechnologischer Prozesse an der Otto-von-Guericke Universität Magdeburg
- seit 2024 PostDoc in der Arbeitsgruppe Prozesssynthese und -dynamik (Prof. Achim Kienle) am Max-Planck Institut für Dynamik komplexer technischer Systeme
- seit 2025 Juniorprofessorin an der Fakultät für Elektrotechnik der Otto-von-Guericke Universität Magdeburg in Kooperation mit dem Max-Planck Institut für Dynamik komplexer technischer Systeme