Prof. Dr. rer. nat. Christoph Hoeschen
Prof. Dr. rer. nat. Christoph Hoeschen
Chair of Medical Systems Technology
Current projects
Precise therapeutic response through personalized, dynamic organ-on-chip (PREDICT)
Duration: 01.06.2024 to 31.12.2027
The main objective of the project is the development of an organ-on-chip system for precision medicine, including the optimization of its use in companion diagnostics to individualize the treatment of tumor patients (with a focus on intestinal tumors) and prevent their metastasis in the micro- and macroenvironment. Organ-on-chip research requires close cooperation and integration with various research teams with interdisciplinary expertise:
(1) Molecular biology and cell culture technology (represented by Prof. Ulf Kahlert)
(2) Metrology and micro/nanotechnology (represented by Prof. Ulrike Steinmann)
(3) Medical imaging techniques and pharmacokinetic process modeling (represented by Prof. Christoph Hoeschen and Dr.-Ing. Melanie Fachet)
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BigTool - Developing a software for image quality analysis in head CT
Duration: 01.10.2024 to 30.09.2027
Based on the developments in the Medirad project and the i-Violin project for determining image quality directly in patient data, an analysis tool is being developed which will be available as a software tool for clinics. It should now also be able to determine the image quality for cranial CT examinations directly in patient images. This objective image quality will be compared with subjective image quality.
The project is being carried out together with our University Hospital and the Municipal Hospital.
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IMMPRINT: Integrated molecular Imaging for Personalized Biomarker-based Breast Cancer Characterization and Treatment
Duration: 01.04.2024 to 01.03.2027
Molecular medical imaging plays a crucial role in modern medical diagnosis, enabling early and personalized therapy for various diseases, especially cancer. However, existing in vivo medical imaging methods have limitations for molecular imaging in humans, such as low sensitivity to molecular processes, limited spatial and temporal resolution, or high exposure to ionizing radiation. To address these challenges, IMMPRINT aims to develop a proof-of-principle demonstrator for in vivo 3D imaging, utilizing X-ray dark-field imaging (DFI) and X-ray fluorescence computed tomography (XFCT) as a novel hybrid tool for personalised tumor profiling, with a specific focus on breast cancer (BC) disease.
DFI will aid the identification of suspicious tumor lesion sites at micrometer scales, followed by a detailed high spatial resolution molecular assessment at the local tumor level using XFCT. As a result of this approach, exposure to body-wide high ionizing radiation doses, as seen in nuclear medical imaging methods, can be confined to regions of interest, thus promoting patient safety. The DF-XFCT will rely on various pillars of innovative technology development, from novel detectors to integrated in vivo, in vitro bio-diagnostics. X-ray fluorescence is emitted when nanoparticles are excited by X-rays. Within IMMPRINT, distinct signatures of intra- and inter-tumor heterogeneity in BC will be identified, which are suitable for detection by specifically designed and targeted nanoparticles. The IMMPRINT system for hybrid DF-XFCT imaging will include standard clinical X-ray sources and will benefit from innovative detectors, enabling concurrent detection of DFI and XFCT, aimed at high spatial and energy resolution.
The unequally distributed data, which includes timing and energy information, requires the development of new methods to extract 3D imaging information from this data, providing insights into the functional, molecular, and anatomical properties of BC disease. The IMMPRINT imaging system will allow new approaches for better medical diagnosis and also new biomedical research. It will demonstrate the technical feasibility on the lab scale and potentially form the basis for the commercial development of a system. The consortium unites expertise from all fields mentioned above and is using nationally and internationally funded large-scale infrastructures.
IMAGEOMICS: Optimizing Benefit/Risk Ratio in Breast Cancer Diagnosis and Radiotherapy: Identifying Molecular, Cellular and Imaging Signatures of Breast Cancer Heterogeneity to Improve Personalized Therapeutic Strategies for Synergistic Treatment Combinations
Duration: 01.02.2024 to 01.01.2027
The main aims of IMAGEOMICS are to improve benefit/risk ratio of breast cancer (BC) patients by identifying patients with a predicted favourable response to combined radiotherapy (RT) and immunotherapy and to develop new imaging modality with increased diagnostic potential and reduced ionizing radiation exposure. These aims will be realized through the following specific objectives: a) investigate how RT influences immunogenic heterogeneity of BC cells of different molecular subtypes using in vitro and in vivo approaches; b) test the applicability of nanoparticles for X ray fluorescence computed tomography (XFCT) to be used for the detection of BC heterogeneity; c) to identify local and systemic signatures that predict patient benefit from combined RT and immunotherapy and test their clinical applicability; d) to integrate data retrieved from experimental models and human studies with epidemiological data to build up a protocol for optimal patient stratification.
Completed projects
breath gas analysis of tuberculosis or lung cancer patients
Duration: 01.12.2016 to 31.12.2024
Lung tuberculosis is an infection of the lungs which had been assumed to be wiped out in modern developed countries. However, there is again a rising number of cases. In addition, due tot he large number of refugees there are additional needs for characterising possible infections early. This is especially true as tuberculosis is still one oft he most often infectual diseases worldwide. X-ray imaging is at least for young patients not an easy to justify procedure. The gold standard for the diagnosis of tuberculosis is the cultural biology prove of Mycobacterium tuberculosis. This is quite a long and complicated procedure. It would be desirable to have a fast and easy diagnostic tool instead, because that could foster the in principle very effective therapy approaches, if applied in early stages. Since we know from earlier studies that breath gas analysis allows the detection of changes in the metabolism and especially those caused by infections we investigate the feasiblity to diagnose tuberculosis with breath gas analysis.
Interventional molecular imaging
Duration: 01.12.2016 to 31.12.2024
Molecular imaging, such as Positron Emission Tomography has an important
impact in diagnostic, while it started only recently to be integrated into interventional procedures. Interventional molecular imaging
can provide guidance to localize a target; provide in-room, post-therapy assessment; monitoring of targeted therapeutics delivery.
Interventional molecular imaging is generally based on commercial whole-body PET/CT scanners, which limit the possibility of an entire surgical guidance
procedure, while on-site integration of dedicated devices would definitely benefit the entire guidance.
This project focuses on the study of a dedicated detector, and the potential impact of its integration in brain interventional procedures.
i-Violin:Implementing verifiable oncological imaging by quality assurance and optimization
Duration: 01.09.2022 to 31.08.2024
An international research team will develop Europe-wide quality and safety standards for the use of ionizing radiation in the diagnosis and treatment of cancer. To this end, a European database with patient-specific diagnostic and therapy data as well as treatment recommendations will be set up. This database is intended to ensure comparable standards for the use of ionizing radiation across national borders and help doctors to reduce the radiation exposure of patients to a reasonable level, optimize it individually and thus improve the safety and quality of care for tumour patients throughout Europe.
The research project focuses on the question of the extent to which the quality of diagnostic imaging, for example computer tomography, is directly related to the dose administered and the success of radiotherapy and can be optimized in such a way that the patient's treatment can be carried out with as few side effects and as few long-term negative effects as possible for the individual patient.
To achieve this goal, the first step is to introduce software developed in preliminary projects to evaluate the image quality of CT scans in five participating European hospitals. Later, the procedures developed in Magdeburg and elsewhere are to be used in as many European hospitals as possible.
The i-Violin project is funded by the EU4Health health program and supports the goal of Europe's Beating Cancer Plan to ensure high standards in cancer treatment. The SAMIRA Action Plan and the strategic research agenda of ESR EuroSafe Imaging and EURAMED programs are also reflected in i-Violin. The partner institutions are the European Institute for Biomedical Imaging Research, the Otto von Guericke University Magdeburg, the University Medical Center of the Johannes Gutenberg University Mainz, the Polytechnic Institute of Coimbra in Portugal, the University of Crete, Greece, the Clinical Hospital Dubrava in Croatia, the University Medical Centre Ljubljana, Slovenia, KU Leuven in Belgium, the University College Dublin, and the National University of Ireland Dublin in Ireland as well as the Finnish Radiation and Nuclear Safety Authority in Finland.
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SINFONIA -Radiation risk appraisal for detrimental effects from medical exposure during management of patients with lymphoma or brain tumour
Duration: 01.09.2020 to 31.08.2024
The overall objective of the 4-year SINFONIA project is to develop novel research methodologies and tools that will provide a comprehensive appraisal of the risk for detrimental effects to patients, workers, the public and the environment from radiation exposure during management of patients suspected or diagnosed with lymphoma and brain tumours.
SINFONIA will develop novel tools and methodologies that will be demonstrated on two suitable clinical examples i.e. lymphoma and brain tumours. However, SINFONIA research outcomes are not confined to the two specific types of diseases. Some of the procedures performed on lymphoma and brain tumour patients are also carried out on patients with other diseases and SINFONIA radiation dose and risk appraisal methods developed for these two groups of patients will be applicable to other diseases
GEPRIS - Signatures from the breath in depression: stress-related changes in the exhaled breath signal during the early phase of disease management
Duration: 01.03.2021 to 29.02.2024
Around a third of patients with a depressive disorder (MDD) do not respond to at least two different antidepressant therapies. These patients need other treatment options as early as possible. Unfortunately, there are currently no non-invasive, easily and frequently applicable biomarkers that could facilitate the diagnosis of unipolar depressive disorder (MDD) or support decision-making on the choice of treatment. Since the lungs act as a gas exchanger between the internal and external environment, the effects of MDD could easily be assessed by analyzing exhaled breath. Such methods are already successfully used in alcohol testing and diabetes mellitus. In a pilot study of 25 patients with MDD and 25 healthy volunteers, we were able to find markers that differed significantly between the groups and that gave a good classification with an accuracy of over 80 % in test and validation samples. The aim of the study is to identify signatures from exhaled air that distinguish a depressive episode in MDD from a healthy state. Furthermore, it will be investigated by which factors (treatment, diet, environment) these signatures are influenced, whether the identified signatures can give indications of the course of the disease and whether they show parallels to the dysregulation of the cortisol response during awakening, which has been shown in depression. In a test sample, 80 patients with MDD according to DSM-V (40 currently free of antidepressant medication and 40 with ongoing antidepressant treatment) and 80 healthy subjects will be included. Furthermore, 40 patients with MDD (20 currently free of antidepressant medication and 20 with ongoing antidepressant treatment) and 40 healthy volunteers will be recruited in a confirmation sample. The clinical examinations and breath measurements will be repeated after 14 and 28 days. The breath will be analyzed using proton transfer reaction mass spectrometry (PTR-TOF-MS). In addition, the underlying substances are determined using GC-GC-TOF-MS. The environmental conditions and the collection method using "Tedlar" bags are controlled. In this way, we want to develop a marker that could support the diagnosis of depression, although this must then be demonstrated in a clinical biomarker study.
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KI-INSPIRE: Collaboration - AI: Artificial intelligence for innovative, sustainable radiation protection of patients in interventional radiology applications
Duration: 01.12.2020 to 31.12.2023
In the field of medical physics and medical technology, the use of AI-based processes is particularly promising in the area of radiation protection, especially in medical imaging, which is responsible for almost 100% of civilization's radiation exposure of 1.9 mSv per year [Information from the Federal Government: Environmental radioactivity and radiation exposure in 2013]. Thanks to the new disruptive technologies of AI, an enormous dose-saving potential could be realized there.
The aim of the joint project is therefore to develop, implement and test AI processes to significantly reduce the radiation dose in medical imaging with ionizing radiation. This is to be achieved by improving image quality and radiation protection for medical imaging procedures based on ionizing radiation.
In order to enable a holistic/holistic and systematic approach, the project addresses interventional imaging in which both diagnostic and therapeutic goals are realized with the help of computed tomography, angiography and nuclear medicine.
A particular focus is on the development and establishment of intelligent algorithms for (I) dose reduction, (II) improvement of image quality and (III) reduction of motion artefacts as well as (IV) interventional characterization of tissue in medical radiation applications - applications that are all part of radiation protection. The focus here is on increasing safety for patients and medical staff, so that a valuable contribution can be made to the positive perception of AI among the general public.
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EURAMED rocc-n-roll - EURopeAn MEDical application and Radiation prOteCtion Concept: strategic research agenda aNd ROadmap interLinking to heaLth and digitisation aspects
Duration: 01.09.2020 to 31.08.2023
Radiation protection in medical applications is well established throughout Europe, however still facing challenges like large differences in procedures between countries, but even within a country or even within a hospital. In addition, new promising approaches like new technologies as e.g. artificial intelligence or personalized medicine approaches need to be investigated regarding their potential for medical radiation protection. The European Alliance for Medical Radiation Protection Research (EURAMED) platform has been found to promote such research in the EC research programme . Together with five other platforms research in the field of radiation protection is promoted basically in the EURATOM framework. Acknowledging the importance of medical applications as the largest man-made source of exposure and the great possibilities of applying ionizing radiation in medicine the EURATOM programme has launched a call for a coordination and support action to develop a strategic research agenda (SRA) on medical applications of ionizing radiation in general allowing to improve links to other programs like HEALTH or DIGITALIZATION.
A consortium called EURAMED rocc-n-roll has been put together to fulfil the task of developing such an SRA partially based on the existing EURAMED SRA on medical radiation protection. In addition it will also develop a roadmap describing how this research agenda can be implemented. An interlink document showing the potential distributions of the different European research programmes to such defined approaches will also be developed. All these documents need to be derived based on a broad consensus of all stakeholders especially also including the patients’ perspective. Therefore, EURAMED rocc-n-roll is based on a series of workshops and writing panels. The workshops will allow contributions by interested stakeholders in person or through members of the consortium.
OvGU is serving as the scientific coordinator of the project.
breath gas analysis in patients suffering from depression
Duration: 01.01.2019 to 31.12.2022
According to Smith (Smith, 2011) brain disorders cost Europe almost €800 billion (US$1 trillion) a year - more than cancer, cardiovascular disease and diabetes together.
Major depressive disorders (MDD) can effectively be treated with psychotherapy and/or antidepressants. However, still one third of patients do not respond and would need different treatment options as early as possible (Kennedy and Giacobbe, 2007).
A possible new method for early detection could be breath gas analysis that already was implemented for alcohol tests and recently was found to be clinical applicability e.g. for diabetes detection. Because the lungs act as a gas exchanger between the internal system and external environment, the internal system in disorders like MDD may be assessed through the analysis of exhaled breath especially with respect to stress induced reactions.
X-ray fluorescence and corresponding anatomical imaging
Duration: 01.09.2014 to 31.12.2022
Molecular imaging today is either limited by systems that provide high resolution spatially and temporarilly but very poor sensitivity to contrast media or molecular markers (CT, MRI) or by such systems that provide high sensitivity but very poor spatial and especially temporal resolution (SPECT, PET). X-ray fluorescence would be an option to overcome such limitations, because in principle it could offer fast scanning, high spatial resolution and a good sensitivity. To gain such efficient approaches one needs scanning geometries with fast steerable X-ray sources which should be adjustable in their beam energy. Such imaging method would on the fly generate an anaomical image as well. We simulate such systems and try to set up demonstration experiments with our cooperation partners.
Advanced X-ray based imaging technologies
Duration: 01.09.2019 to 31.08.2022
We build systems for dark field and absorption based X-ray imaging systems using for example scanning beam technologies, develop and characterise corresponding detector systems and imaging geometries. The total systems for both different types of imaging systems will be simulated and transferred into prototypes.
Biokinetics of radiopharmaceuticals
Duration: 01.06.2019 to 30.06.2022
In order to optimize radiation protection for the patient and for optimal image acquisition, it is essential to know the distribution of radiopharmaceuticals in the body over time. As this is not trivial to measure for every patient, nuclear medicine data is recorded over time in cooperation with clinics. This is used to create dynamic compartment models and determine the parameters. The uncertainty in the determination of the parameters and the sensitivity of the model for the individual parameters are examined in order to determine which influencing parameters are particularly significant. Subsequently, real patient data can be compared with the model predictions in order to find optimized time schedules for imaging and optimized therapy parameters or to improve dosimetry for the patient.
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Breast-CT basierend auf CT dOr
Duration: 01.06.2016 to 31.12.2021
A newly designed especially developed breast CT system based on the newly developed CT d Or geometry and in this case based on an electron gun with a dedicated delineation system and a special target ring had been set-up. This would allow very fast scanning and a larger covering of the breast volume (closer tot he breast wall) than current breast CT systems, from which very few exist. However, the new geometry requires a very new approach for a detector system because it has tob e separated in columns and the electronics need tob e conserved and should not cover the source positions. We simulate the possible detector design, develop a prototype electronic system and a prototype detector
Darkfield Imaging for breast tissue
Duration: 01.09.2016 to 30.06.2021
Darkfield imaging relies on differences in the scatter component of the x-ray distribution due to differences instructural conditions oft he tissue. In many approaches this component is a side-product of phase contrast imaging. Since phase contrast imaging is strongly dependent on movements oft he patient and it will be dose intensive for applications in the human tissue characterisation for in vivo imaging, we are concentrating on darkfield X-ray imaging directly. A special system for dose-optimised imaging will be developed. We focus on breast imaging within the current project.
Pharmacokinetics with molecular imaging
Duration: 01.05.2019 to 30.06.2021
New molecular imaging techniques based on monoenergetic X-ray sources and X-ray fluorescence imaging, for example, allow nanoparticles to be tracked in the body. If such nanoparticles are coupled to pharmaceuticals, it is possible to track their presence in the body at different points in time and thus ensure the optimal effectiveness of the pharmaceuticals. Imaging is not yet fully available, so the special reconstruction is to be developed in this project to enable 3D representations. In addition, the data must be fitted into kinetic models in order to be able to make predictions about the most likely courses of accumulation in the body.
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image quality analysis on patient images - EU Projekt MEDIRAD
Duration: 01.06.2017 to 31.05.2021
Medical imaging quality description is today either based on investigating with objective physical mathematical methods images of certain test objects or on subjective reader evaluations. The objective methods can be either based on methods applicable in the Fourier domain or those in the spatial domain. While analytics in the Fourier domain are often quite easy they are often difficult to interpret in terms of provided diagnostic performance. Image quality analysis in the spatial domain is on the other hand typically limited to very specific tasks and complicated to perform. Human reader studies very often result in very different results and are very time consuming. We want to develop a way to characterise patient images based on physical methods to describe image quality so that fast objective measurements correspond to human reader studies. That would allow qulaity assurance on real patient images in the future.
Robot driven CT with WATCH geometry KaribiCT
Duration: 15.05.2016 to 30.11.2020
The newly developed geometry for CT applications called WATCH allows a CT scan with variable resolution, in a lying as well as a sitting and standing patient position. It is an open system with easy access fort he radiologist and can be driven by a robot system. However, although the system and the used reconstruction should be very tolerant against movement errors, that would not be the case for geometrical misalignments. Therefore we focus on setting up the robot driven system with a 3D imaging detector and a calibration system. This calibration system can be used for standard CT as well.
Sub-100 ps TOF CRT impact in interventional molecular brain imaging
Duration: 01.08.2015 to 31.07.2020
Time Of Flight (TOF) capability in PET imaging enhances Signal to Noise Ratio in inverse proportion to the temporal resolution. The Coincidence Resolving Time (CRT) in commercial PET scanners is about 500 ps (FWHM) but current technology limit approaches 10 ps CRT (FWHM) corresponding to 1.5 mm spatial resolution.
TOF increases lesion detection capability, the robustness of iterative reconstruction, and reduces bias in quantification through improved
attenuation, scatter, and random corrections. This investigation studies through simulations the possible enhancements in brain imaging of sub-100 ps CRT technology, in both static and dynamic brain studies.
We will develop prototyp PET detectors.
CT-characterisation of bowtiefilters and parameters for dosimetric calculations
Duration: 01.11.2014 to 31.12.2019
CT imaging is the largest man-made source of ionising radiation to the public in developed countries as in Germany. Here more than 60% oft he effective dose delivered to patients is due to CT examinations. However, since only small parts oft he body are exposed to ionising radiation, there are quite large dosest o single organs. To evaluate the dose distributions and ist potential effects further it is necessary to determine dose distributions to various organs in detail. Since it is impossible to measure such doses inside the body simulations have tob e performed. There accuracy depends strongly on an exact characterisation oft he CT parameters including calibrating dose measurements and determination or characterisation o feg the bowtie filter of CT systems. There are various measurements developed and performed to characterise bowtie filters and dose values as a basis fort he following simulation of patient dose distributions.
SAFIR - Small Animal Fast Insert for mRi
Duration: 01.10.2016 to 30.09.2019
SAFIR (Small Animal Fast Insert for mRi) is an innovative, high rate PET detector insert for MRI to be used for quantitative dynamic small animal imaging inside the bore of a commercial 7T MRI preclinical scanner (Bruker 70/30, http://tinyurl.com/BrukerBiospec) at the University Zurich, Institute of Pharmacology and Toxicology. The project targets an unprecedented temporal resolution (about 5 seconds) and truly simultaneous PET/MR acquisition
The use of diamond detectors for dosimetry and microdosimetry assessment in different therapeutic scenarios
Duration: 01.07.2016 to 30.06.2018
In cancer treatment both ion-beam therapy and alpha radionuclide therapy base their effectiveness on the high ionization density provided by hadrons. However the stochastic nature of the hadron interaction in tissue, and the complexity of the interaction patterns
require a better description of the radiobiological effect of hadrons in tissue that cannot be
adequately reflected, as in conventional radiation therapy, by a single dosimetric quantity,
e.g. mean absorbed dose to target volume. MedAustron, the Austrian centre for ion-beam therapy, in collaboration with the University of Rome, Tor Vergata is developing semi-conductor diamond detectors for dosimetry and microdosimetry in ion-beam therapy. The potential of such (micro)dosimeters with respect to alpha radionuclide target therapy, 90Y radio-embolization, and other treatment modalities is under investigation in the present project.
2024
Abstract
PP23.04 X-ray flourescence imaging using bragg diffractionbased focusing with graphite optics - a simulation study
Kumar, Kunal; Fachet, Melanie; Hoeschen, Christoph
In: Physica medica - Amsterdam : Elsevier, Bd. 125 (2024), S. S260, Artikel 103826
P01.23 AI-based risk assessment for hyperinflammatory patterns and infectious outcomes from blood biomarkers in patients with polytraumatic injuries
Fachet, Melanie; Mushunuri, R. V.; Bergmann, C.; Relja, B.; Hoeschen, Christoph
In: Physica medica - Amsterdam : Elsevier, Bd. 125 (2024), Heft Supplement 1, S. S383 [Part of special issue: Abstracts of the 5th European Congress of Medical Physics, 11 September 2024 - 14 September 2024]
P07.23 Visibility investigation and feasiibility study of a new compact x-ray dark-field imaging setup and corresponding image optimization
Yan, Xiaolei; Hoeschen, Christoph
In: Physica medica - Amsterdam : Elsevier, Bd. 125 (2024), Heft Supplement 1, S. S467 [Part of special issue: Abstracts of the 5th European Congress of Medical Physics, 11 September 2024 - 14 September 2024]
Article in journal
3D-visualization of segmented contacts of directional deep brain stimulation electrodes via registration and fusion of CT and FDCT
Al-Jaberi, Fadil; Moeskes, Matthias; Skalej, Martin; Fachet, Melanie; Hoeschen, Christoph
In: EJNMMI reports - [Cham] : Springer International Publishing, Bd. 8 (2024), S. 1-21, Artikel 17
Book chapter
Computed tomography optimization using a volumetric channelized Hotelling observer approach for energy integrating and photon-counting CT scanners
Petrov, Dimitar; Yegin, Gizem; Hoeschen, Christoph; Bosmans, Hilde
In: Proceedings of SPIE - Bellingham, Wash. : SPIE, Bd. 12929 (2024), S. 127 [Konferenz: Medical Imaging 2024, San Diego, California, United States, 20-22 February 2024]
Peer-reviewed journal article
Enabling low-dose in vivo benchtop X-ray fluorescence computed tomography through deep-learning-based denoising
Mahmoodian, Naghmeh; Rezapourian, Mohammad; Inamdar, Asim Abdulsamad; Kumar, Kunal; Fachet, Melanie; Hoeschen, Christoph
In: Journal of imaging - Basel : MDPI, Bd. 10 (2024), Heft 6, Artikel 127, insges. 15 S.
The use of dose management systems in Europe - results of an ESR EuroSafe imaging questionnaire
Loose, Reinhard; Vano, Eliseo; Ammon, Josefin; Andersson, Jonas; Brat, Hugues; Brkljacic, Boris; Caikovska, Katrina; Corridori, Riccardo; Damilakis, John; De Bondt, Timo; Frija, Guy; Granata, Claudio; Hoeschen, Christoph; Kotter, Elmar; Kralik, Ivana; McNulty, Jonathan; Paulo, Graciano; Tsapaki, Virginia
In: Insights into imaging - Berlin : Springer, Bd. 15 (2024), Artikel 201, insges. 8 S.
High-spatial-resolution benchtop X-ray fluorescence imaging through bragg-diffraction-based focusing with bent mosaic graphite crystals - a simulation study
Kumar, Kunal; Fachet, Melanie; Hoeschen, Christoph
In: International journal of molecular sciences - Basel : Molecular Diversity Preservation International, Bd. 25 (2024), Heft 9, Artikel 4733, insges. 26 S.
2023
Abstract
Nachweis psychischer Beanspruchung bei Stressreaktionen im Arbeitsumfeld durch objektive und subjektive Messverfahren
Steigemann, Lea Marie; Wagner, L. M.; Cholewinski, D.; Haase, Tina; Fachet, Melanie; Böckelmann, Irina; Darius, Sabine; Arlinghaus, Julia C.; Hoeschen, Christoph
In: 54. Jahrestagung der Deutschen Gesellschaft für Medizinische Physik, DGMP 2023 / Deutsche Gesellschaft für Medizinische Physik , 2023 - [Berlin] : [Deutsche Gesellschaft für Medizinische Physik e.V.], S. 166-167, Artikel PS03.09 [Konferenz: 54. Jahrestagung der Deutschen Gesellschaft für Medizinische Physik, DGMP 2023, Magdeburg, 27.-30.09. 2023]
New insight into peripheral molecular change in major depressive disorder by breathomics analysis
Gbaoui, Laila; Hoeschen, Christoph; Fachet, Melanie; Lüno, Marian; Meyer-Lotz, Gabriela; Frodl, Thomas
In: Konferenz: 54. Jahrestagung der Deutschen Gesellschaft für Medizinische Physik, DGMP 2023, Magdeburg, 27.-30.09. 2023, 54. Jahrestagung der Deutschen Gesellschaft für Medizinische Physik, DGMP 2023 / Deutsche Gesellschaft für Medizinische Physik , 2023 - [Berlin] : [Deutsche Gesellschaft für Medizinische Physik e.V.], S. 348-349, Artikel AS16.03
Atemgasanalyse zur Beurteilung und Erfassung von psychischer Beanspruchung bei Stressreaktionen im Arbeitsumfeld
Fachet, Melanie; Haase, Tina; Steigemann, Lea-Marie; Wagner, Leonie Marlene; Cholewinski, D.; Darius, Sabine; Böckelmann, Irina; Arlinghaus, Julia C.; Hoeschen, Christoph
In: 54. Jahrestagung der Deutschen Gesellschaft für Medizinische Physik, DGMP 2023 / Deutsche Gesellschaft für Medizinische Physik , 2023 - [Berlin] : [Deutsche Gesellschaft für Medizinische Physik e.V.], S. 350-351, Artikel AS16.04 [Konferenz: 54. Jahrestagung der Deutschen Gesellschaft für Medizinische Physik, DGMP 2023, Magdeburg, 27.-30.09. 2023]
Book chapter
Multi-class Tissue Segmentation of CT images using an Ensemble Deep Learning method
Mahmoodian, Naghmeh; Chakrabarty, Sumit; Georgiades, Marilena; Pech, Maciej; Hoeschen, Christoph
In: 2023 45th Annual International Conference of the IEEE Engineering in Medicine & Biology Conference (EMBC) / IEEE Engineering in Medicine and Biology Society , 2023 - Piscataway, NJ : IEEE, insges. 4 S. [Konferenz: 45th Annual International Conference of the IEEE Engineering in Medicine & Biology Society (EMBC), Sydney, Australia, 24-27 July 2023]
Peer-reviewed journal article
Utilizing predictive machine-learning modelling unveils feature-based risk assessment system for hyperinflammatory patterns and infectious outcomes in polytrauma
Fachet, Melanie; Mushunuri, Raghava Vinaykanth; Bergmann, Christian B.; Marzi, Ingo; Hoeschen, Christoph; Relja, Borna
In: Frontiers in immunology - Lausanne : Frontiers Media, Bd. 14 (2023), insges. 15 S.
Artifacts’ detection for MRI non-metallic needles - comparative analysis for artifact evaluation using K-means and manual quantification
AL-Maatoq, Marwah; Fachet, Melanie; Rao, Rajatha Nagaraja; Hoeschen, Christoph
In: Magnetochemistry - Basel : MDPI, Bd. 9 (2023), Heft 3, Artikel 79, insges. 13 S.
Characterization of a polychromatic microfocus X-ray fluorescence imaging setup with metallic contrast agents in a microphysiological tumor model
Kumar, Kunal; Fachet, Melanie; Al-Maatoq, Marwah; Chakraborty, Amit; Khismatrao, Rahul S.; Oka, Shreyas V.; Staufer, Theresa; Grüner, Florian; Michel, Thilo; Walles, Heike; Hoeschen, Christoph
In: Frontiers in physics - Lausanne : Frontiers Media, Bd. 11 (2023), Artikel 1125143, insges. 19 S.
Gut-brain axis volatile organic compounds derived from breath distinguish between schizophrenia and major depressive disorder
Henning, Dariush; Lüno, Marian; Jiang, Carina; Meyer-Lotz, Gabriela; Hoeschen, Christoph; Frodl, Thomas
In: Journal of psychiatry & neuroscience - Ottawa : CMA, Bd. 48 (2023), Heft 2, S. E117-E125
Dynamic stability of volatile organic compounds in respiratory air in schizophrenic patients and its potential predicting efficacy of TAAR agonists
Held, Anna; Henning, Dariush; Jiang, Carina; Hoeschen, Christoph; Frodl, Thomas
In: Molecules - Basel : MDPI, Bd. 28 (2023), Heft 11, Artikel 4385, insges. 15 S.
Optimization techniques for semi-automated 3D rigid registration in multimodal image-guided deep brain stimulation
Al-Jaberi, Fadil; Fachet, Melanie; Moeskes, Matthias; Skalej, Martin; Hoeschen, Christoph
In: Current directions in biomedical engineering - Berlin : De Gruyter, Bd. 9 (2023), Heft 1, S. 355-358
Möglichkeiten der künstlichen Intelligenz im Strahlenschutz
Pashazadeh, Ali Mahmout; Hoeschen, Christoph
In: Die Radiologie - [Berlin] : Springer Medizin Verlag GmbH, Bd. 63 (2023), Heft 7, S. 530-538
Estimation of central blood pressure waveform from femoral blood pressure waveform by blind sources separation
Gbaoui, Laila; Hoeschen, Christoph; Kaniusas, Eugenijus; Khatib, Saher; Gretschel, Stephan; Wellnhofer, Ernst
In: Frontiers in Cardiovascular Medicine - Lausanne : Frontiers Media, Bd. 10 (2023), insges. 14 S.
Education and training in radiation protection in Europe - results from the EURAMED Rocc-n-Roll project survey
Santos, Joana; Foley, Shane; Andersson, Jonas; Figueiredo, João Paulo; Hoeschen, Christoph; Damilakis, John; Frija, Guy; Alves, Francisco; Riklund, Katrine; Rainford, Louise; Nestle, Ursula; McNulty, Jonathan; Bacher, Klaus; Hierath, Monika; Paulo, Graciano
In: Insights into imaging - Berlin : Springer, Bd. 14 (2023), Artikel 55, insges. 10 S.
Modelling DTPA therapy following Am contamination in rats
Kastl, Manuel; Grémy, Olivier; Lamart, Stephanie; Giussani, Augusto; Li, Wei Bo; Hoeschen, Christoph
In: Radiation and environmental biophysics - Berlin : Springer, Bd. 62 (2023), Heft 4, S. 483-495
Calculation of standardized uptake values (SUVs) and time activity curves (TACs) of mice in FDG-PET
Jafarian Dehkordi, Forough; Tanha, Kaveh; Hoeschen, Christoph
In: Current directions in biomedical engineering - Berlin : De Gruyter, Bd. 9 (2023), Heft 1, S. 118-121
U-Net-based SUV calculation in FDG-PET imaging of mice brain for enhanced analysis
Pashazadeh, Ali Mahmout; Jafarian Dehkordi, Forough; Tanha, Kaveh; Hoeschen, Christoph
In: Current directions in biomedical engineering - Berlin : De Gruyter, Bd. 9 (2023), Heft 1, S. 291-294
Simulation study of the effect of the geometrical parameters on the performance of a beta probe
Pashazadeh, Ali Mahmout; Hoeschen, Christoph
In: Current directions in biomedical engineering - Berlin : De Gruyter, Bd. 9 (2023), Heft 1, S. 299-302
The potential role of 3D-printed phantoms in quality control of artificial intelligence-based algorithms in medical imaging
Pashazadeh, Ali Mahmout; Hoeschen, Christoph
In: Current directions in biomedical engineering - Berlin : De Gruyter, Bd. 9 (2023), Heft 1, S. 295-298
2022
Abstract
Atemgasanalytik mittels Proton Transfer Reaction-Massenspektrometrie (PTR-MS) - Einfluss von Alltagsfaktoren auf die Messergebnisse
Reckzeh, Marie-Louise; Lowitzki, Simon; Walles, Thorsten; Hoeschen, Christoph; Fachet, Melanie
In: Zentralblatt für Chirurgie - Stuttgart [u.a.]: Thieme, 2000, Bd. 147 (2022), S 01, S. S84
Book chapter
Detruncation of clinical CT scans using a discrete algebraic reconstruction technique prior
Byl, Achim; Knaup, Michael; Rafecas, Magdalena; Hoeschen, Christoph; Kachelrieß, Marc
In: 7th International Conference on Image Formation in X-Ray Computed Tomography / ICIFXCT , 2022 - Bellingham, Washington, USA : SPIE, S. 1-7, Artikel 123041M, insges. 7 S. [Konferenz: Seventh International Conference on Image Formation in X-Ray Computed Tomography, ICIFXCT 2022, Baltimore, United States, 2022]
Liver texture classification on CT images of microwave ablation therapy
Mahmoodian, Naghmeh; Thadesar, Harshita; Georgiades, Marilena; Pech, Maciej; Hoeschen, Christoph
In: 2022 7th International Conference on Data Science and Machine Learning Applications , 2022 - Piscataway, NJ : IEEE, S. 139-144 [Konferenz: 7th International Conference on Data Science and Machine Learning Applications, CDMA, Riyadh, Saudi Arabia, 01-03 March 2022]
Peer-reviewed journal article
Exploring the translational challenge for medical applications of ionising radiation and corresponding radiation protection research
Bockhold, Sophie; Foley, Shane J.; Rainford, Louise A.; Corridori, Riccardo; Eberstein, Annika; Hoeschen, Christoph; Konijnenberg, Mark W.; Molyneux-Hodgson, Susan; Paulo, Graciano; Santos, Joana; McNulty, Jonathan P.
In: Journal of translational medicine - London: BioMed Central, Bd. 20 (2022), 1, insges. 10 S.
Breathomics profiling of metabolic pathways affected by major depression - possibilities and limitations
Gbaoui, Laila; Fachet, Melanie; Lüno, Marian; Meyer-Lotz, Gabriele; Frodl, Thomas; Hoeschen, Christoph
In: Frontiers in psychiatry - Lausanne: Frontiers Research Foundation, Bd. 13 (2022), insges. 17 S.
Volatile organic compounds from exhaled breath in schizophrenia
Jiang, Carina; Dobrowolny, Henrik; Gescher, Dorothee Maria; Meyer-Lotz, Gabriela; Steiner, Johann; Hoeschen, Christoph; Frodl, Thomas
In: The world journal of biological psychiatry - Abingdon: Taylor & Francis Group, 2000, Bd. 23 (2022), 10, S. 773-784
Medical applications of ionizing radiation and radiation protection for European patients, population and environment
Thierry-Chef, Isabelle; Cardis, Elisabeth; Damilakis, John; Frija, Guy; Hierath, Monika; Hoeschen, Christoph
In: EPJ Nuclear Sciences & Technologies - Les Ulis : EDP Sciences, Bd. 8 (2022), Artikel 44, insges. 8 S.
Carbon nanotube-based reinforced polymers for medical applications - improving impact strength of polymer-polymer composites
AL-Maatoq, Marwah; Fuentealba, Patricio; Fachet, Melanie; Glüge, Rainer; Ali, Salah H. R.; Hoeschen, Christoph
In: Journal of nanomaterials - New York, NY : Hindawi Publ., Bd. 2022 (2022), Artikel 1760198, insges. 15 S.
Education and training in radiation protection in Europe - an analysis from the EURAMED rocc-n-roll project
Rainford, Louise; Santos, Joana; Alves, Francisco; Figueiredo, João Paulo; Hoeschen, Christoph; Damilakis, John; Frija, Guy; Andersson, Jonas; McNulty, Jonathan; Foley, Shane; Bacher, Klaus; Nestle, Ursula; Hierath, Monika; Paulo, Graciano
In: Insights into imaging - Berlin : Springer, Bd. 13 (2022), Artikel 142, insges. 10 S.
Investigation of everyday influencing factors on the variability of exhaled breath profiles in healthy subjects
Fachet, Melanie; Lowitzki, Simon; Reckzeh, Marie-Louise; Walles, Thorsten; Hoeschen, Christoph
In: Current directions in biomedical engineering - Berlin: De Gruyter, 2015, Bd. 8 (2022), 2, S. 261-264
Comparison of the Y-90 brachytherapy and Ir-192 brachytherapy of skin tumors - a simulation study
Pashazadeh, Ali; Hoeschen, Christoph
In: Current directions in biomedical engineering - Berlin: De Gruyter, Bd. 8 (2022), 2, S. 388-391
Susceptibility artifacts evaluation for non-metallic biopsy needles in a biological-engineered 3D tumor model
Al-Maatoq, Marwah; Fachet, Melanie; Walles, Heike; Hoeschen, Christoph
In: Current directions in biomedical engineering - Berlin : De Gruyter, Bd. 8 (2022), 2, S. 289-292
Science and practice of imaging physics through 50 years of SPIE Medical Imaging conferences
Wang, Adam S.; Cunningham, Ian A.; Danielsson, Mats; Fahrig, Rebecca; Flohr, Thomas; Hoeschen, Christoph; Noo, Frederic; Sabol, John M.; Siewerdsen, Jeffrey H.; Tingberg, Anders; Yorkston, John I.; Zhao, Wei; Samei, Ehsan
In: Journal of medical imaging - [Bellingham, Wash.]: SPIE, Bd. 9 (2022), S1
Volatile organic compounds from breath differ between patients with major depression and healthy controls
Lueno, Marian; Dobrowolny, Henrik; Gescher, Dorothee Maria; Gbaoui, Laila; Meyer-Lotz, Gabriele; Hoeschen, Christoph; Frodl, Thomas
In: Frontiers in psychiatry - Lausanne: Frontiers Research Foundation, 2007, Bd. 13 (2022), insges. 8 S.
Segmentation of living and ablated tumor parts in CT images using ResLU-Net
Mahmoodian, Naghmeh; Thadesar, Harshita; Sadeghi, Maryam; Georgiades, Marilena; Pech, Maciej; Hoeschen, Christoph
In: Current directions in biomedical engineering - Berlin : De Gruyter, Bd. 8 (2022), Heft 2, S. 49-52
A concept to combine a gamma probe with ultrasound imaging for improved localization of sentinel lymph nodes - a feasibility study of the concept
Pashazadeh, Ali; Hoeschen, Christoph; Großer, Oliver Stephan; Kreißl, Michael; Kupitz, Dennis; Boese, Axel; Illanes, Alfredo; Friebe, Michael
In: Current directions in biomedical engineering - Berlin: De Gruyter, 2015, Bd. 8 (2022), 2, S. 380-383
Fifty years of SPIE Medical Imaging proceedings papers
Nishikawa, Robert M.; Deserno, Thomas Martin; Madabhushi, Anant; Krupinski, Elizabeth A.; Summers, Ronald M.; Hoeschen, Christoph; Mello-Thoms, Claudia R.; Myers, Kyle J.; Kupinski, Matthew A.; Siewerdsen, Jeffrey H.
In: Journal of medical imaging - [Bellingham, Wash.]: SPIE, Bd. 9 (2022), S1
Notifications and alerts in patient dose values for computed tomography and fluoroscopy-guided interventional procedures
Vano, Eliseo; Loose, Reinhard; Frija, Guy; Paulo, Graciano; Efstathopoulos, Efstathios; Granata, Claudio; Corridori, Riccardo; Torresin, Alberto; Andersson, Jonas S.; Tsapaki, Virginia; Ammon, Josefin; Hoeschen, Christoph
In: European radiology - Berlin: Springer, Bd. 32 (2022), 8, S. 5525-5531
Dissertation
Quality assessment of clinical thorax CT images
Passand, Zahra; Hoeschen, Christoph
In: Magdeburg: Universitätsbibliothek, Dissertation Otto-von-Guericke-Universität Magdeburg, Fakultät für Elektrotechnik und Informationstechnik 2022, 1 Online-Ressource (II, 101 Seiten, 7,43 MB) [Literaturverzeichnis: Seite 87-99]
2021
Abstract
Liver ablation segmentation of CT images in microwave ablation therapy
Mahmoodian, Naghmeh; Georgiades, Marilena; Hoeschen, Christoph
In: 5th Conference on Image-Guided Interventions (IGIC) , 2021 - Magdeburg : [Otto-von-Guericke University Magdeburg] ; Hansen, Christian *1980-*, S. 13 [Konferenz: 5th Conference on Image-Guided Interventions, IGIC 2021, Magdeburg, 13-14 October 2021]
Multimodal image fusion for determination of electrode location in deep brain stimulation
Al-Jaberi, Fadil; Fachet, Melanie; Moeskes, Matthias; Skalej, Martin; Hoeschen, Christoph
In: 5th Conference on Image-Guided Interventions (IGIC)/ Conference on Image-Guided Interventions - Magdeburg: [Otto-von-Guericke University Magdeburg], 2021; Hansen, Christian *1980-* . - 2021, S. 49
Peer-reviewed journal article
ESR EuroSafe Imaging and its role in promoting radiation protection - 6 years of success
Frija, Guy; Hoeschen, Christoph; Granata, Claudio; Vano, Eliseo; Paulo, Graciano; Damilakis, John; Donoso, Lluis; Bonomo, Lorenzo; Loose, Reinhard; Ebdon-Jackson, Steve
In: Insights into imaging - Berlin : Springer, Bd. 12 (2021), Heft 1, Artikel 3, insges. 12 S.
Quantitative imaging of bone remodeling in patients with a unicompartmental joint unloading knee implant (ATLAS Knee System) - effect of metal artifacts on a SPECT-CT-based quantification
Großer, Oliver Stephan; Klutzny, Marcus; Wissel, Heiko; Kupitz, Dennis; Finger, Michael; Schenke, Simone; Wüstemann, Jan; Lohmann, Christoph H.; Hoeschen, Christoph; Pech, Maciej; Stärke, Christian; Kreißl, Michael
In: EJNMMI Physics - Berlin: SpringerOpen, Bd. 8 (2021), Artikel 15, insges. 15 S.
Dissertation
X-ray fluorescence imaging - experimental and numerical analysis of a crystal based concept
Rosentreter, Tanja; Hoeschen, Christoph
In: Magdeburg, Dissertation Otto-von-Guericke-Universität Magdeburg, Fakultät für Naturwissenschaften 2021, x, 147 Seiten [Literaturverzeichnis: Seite 137-144][Literaturverzeichnis: Seite 137-144]
2020
Abstract
Breathomics for depressive disorders
Lüno, Marian; Meyer-Lotz, Gabriela; Metzger, Coraline Danielle; Gescher, Dorothee Maria; Hoeschen, Christoph; Gbauoui, Laila; Frodl, Thomas
In: Pharmacopsychiatry - Stuttgart [u.a.] : Thieme - Bd. 53.2020, 2, P.2.7, S. 83
Book chapter
Image quality assessment of real patient thorax CT images using modulation transfer function and noise power spectrum
Passand, Zahra; Hoeschen, Christoph
In: Proceedings of SPIE/ SPIE - Bellingham, Wash.: SPIE, 1963, Bd. 11312.2020[Konferenz: Medical Imaging 2020, 15-20 February 2020]
Peer-reviewed journal article
Einsatz künstlicher Intelligenz für die Bildrekonstruktion
Hoeschen, Christoph
In: Der Radiologe - Berlin: Springer, Bd. 60 (2020), 1, S. 15-23
Clinical and epidemiological observations on individual radiation sensitivity and susceptibility
Seibold, Petra; Auvinen, Anssi; Averbeck, Dietrich; Bourguignon, Michel; Hartikainen, Jaana M.; Hoeschen, Christoph; Laurent, Olivier; Noel, Georges; Sabatier, Laure; Salomaa, Sisko; Blettner, Maria
In: International journal of radiation biology - London: Taylor & Francis, Bd. 96.2020, 3, S. 324-339
Current status of radioactive waste management in Afghanistan
Tanha, Mohammad R.; Hanafiah, Marlia M.; Khalid, Fazal R.; Storai, Mohammad A.; Hoeschen, Christoph
In: Journal of radioanalytical and nuclear chemistry: an international journal dealing with all aspects and applications of nuclear chemistry - Dordrecht [u.a.]: Springer Science + Business Media B.V., Bd. 323.2020, 2, S. 715-720
Potential screening assays for individual radiation sensitivity and susceptibility and their current validation state
Gomolka, Maria; Blyth, Benjamin; Bourguignon, Michel; Badie, Christophe; Schmitz, Annette; Talbot, Christopher; Hoeschen, Christoph; Salomaa, Sisko
In: International journal of radiation biology - London: Taylor & Francis, Bd. 96.2020, 3, S. 280-296
2019
Book chapter
Activity concentration and annual effective dose estimation of 210Pb, 40K and 137Cs in soils of southern Algeria
Nadri, M.; Tanha, Mohammad R.; Hoeschen, Christoph; Khiari, C.; Ioannidou, A.
In: International journal of environmental science and technology: IJEST - Tehran: Islamic Azad University, 2019[Online first]
Peer-reviewed journal article
Assessment of radiation protection and awareness level among radiation workers and members of the public in Afghanistan - a pilot study
Tanha, Mohammad R.; Khalid, Fazal Rahman; Hoeschen, Christoph
In: Journal of radiological protection - Bristol: IOP Publ. . - 2019
A method of determining geometry of cone beam CT scanner
Tischenko, Oleg; Saeidnezhad, Nazila; Hoeschen, Christoph
In: Biomedical physics & engineering express - Bristol: IOP Publ., Bd. 5 (2019), 5, insges. 14 S.
Strategic research agenda for biomedical imaging
Aime, S.; Alberich, A.; Almen, A.; Arthurs, O. J.; Barthel, H.; Clément, O.; Crean, M.; Souza, N.; Demuth, F.; Dewey, V.; Dousset, V.; Frangi, A.; Garos, C.; Golay, X.; Gordebeke, P.; Günther, M.; Hahn, H.; Hierath, M.; Hoeschen, Christoph; Hunink, M.; Kauczor, H. U.; Krestin, G.; Krischak, K.; Langs, G.; Liu, Y.; Marti-Bonmati, L.; Matos, C.; Mayerhofer-Sebera, U.; McNulty, J.; Muylle, K.; Neeman, M.; Niessen, W.; Nikolaou, K.; Pereira, P.; Persson, A.; Pifferi, A.; Riklund, K.; Rockall, A.; Rosendahl, K.; Sardanelli, F.; Sourbron, S.; Speck, Oliver; Valentini, V.; Zolda, P.
In: Insights into imaging - Berlin: Springer, Volume 10 (2019), article number 7,insgesamt 14 Seiten
2018
Book chapter
Assessment of image quality parameters of a novel micro-CT system compared to a conventional CT geometry
Kumar, Kunal; Saeidnezhad, Nazila; Müller, Bernhard H.; Tischenko, Oleg; Hoeschen, Christoph
In: Konferenz: SPIE Medical Imaging, 2018, Houston, Texas, United States, Proceedings of SPIE/ SPIE - Bellingham, Wash.: SPIE, Bd. 10573 (2018)
Peer-reviewed journal article
Lifetime study in mice after acute low-dose ionizing radiation - a multifactorial study with special focus on cataract risk
Dalke, Claudia; Neff, Frauke; Kaur Bains, Savneet; Bright, Scott; Lord, Deborah; Reitmeir, Peter; Rößler, Ute; Samaga, Daniel; Unger, Kristian; Braselmann, Herbert; Wagner, Florian; Greiter, Matthias; Gomolka, Maria; Hornhardt, Sabine; Kunze, Sarah; Kempf, Stefan J.; Garrett, Lillian; Hölter-Koch, Sabine; Wurst, Wolfgang; Rosemann, Michael; Azimzadeh, Omid; Tapio, Soile; Aubele, Michaela; Theis, Fabian; Hoeschen, Christoph; Slijepcevic, Predrag; Kadhim, Munira; Atkinson, Michael; Zitzelsberger, Horst; Kulka, Ulrike; Graw, Jochen
In: Radiation and environmental biophysics - Berlin : Springer . - 2018, insges. 15 S.
Determination and verification of the x-ray spectrum of a CT scanner
Hassan, Ahmad Ibrahim; Skalej, Martin; Schlattl, Helmut; Hoeschen, Christoph
In: Journal of medical imaging - [Bellingham, Wash.] : SPIE - Bd. 5.2018, 1, Art.-Nr. 013506, insges. 15 S.
Localising functionalised gold-nanoparticles in murine spinal cords by X-ray fluorescence imaging and background-reduction through spatial filtering for human-sized objects
Grüner, F.; Blumendorf, F.; Schmutzler, O.; Staufer, T.; Bradbury, M.; Wiesner, U.; Rosentreter, T.; Loers, G.; Lutz, D.; Richter, B.; Fischer, M.; Schulz, F.; Steiner, S.; Warmer, M.; Burkhardt, A.; Meents, A.; Kupinski, M.; Hoeschen, Christoph
In: Scientific reports - [London]: Macmillan Publishers Limited, part of Springer Nature, Vol. 8.2018,1, Artikelnummer 16561
EURAMEDs vision on medical radiation protection (research)
Hoeschen, Christoph
In: Annals of the ICRP/ International Commission on Radiological Protection - London [u.a.]: Sage, Bd. 47 (2018), 3-4, S. 152-158
A systemic view on the distribution of diet-derived methanol and hepatic acetone in mice
Kistler, Martin; Muntean, Andreea; Höllriegl, Vera; Matuschek, Georg; Zimmermann, Ralf; Hoeschen, Christoph; Hrabě de Angelis, Martin; Rozman, Jan
In: Journal of breath research: volatiles for medical diagnosis : official journal of the International Association for Breath Research (IABR) and the International Society for Breath Odor Research (ISBOR) - Bristol: IOP, Bd. 12.2018, 1, insges. 9 S.
2017
Book chapter
Novel method to calibrate CT scanners with a conic probe body
Tischenko, O.; Saeednejad, N.; Hoeschen, Christoph
In: Proceedings of SPIE - Bellingham, Wash. : SPIE, Bd. 10132 (2017), Artikel 101322Q
Experimental investigation of a HOPG crystal fan for x-ray fluorescence molecular imaging
Rosentreter, Tanja; Müller, Bernhard; Schlattl, Helmut; Hoeschen, Christoph
In: Proceedings of SPIE - Bellingham, Wash. : SPIE, Bd. 10132 (2017), Artikel 101325P
Peer-reviewed journal article
Feasibility of reducing differences in estimated doses in nuclear medicine between a patient-specific and a reference phantom
Zvereva, Alexandra; Schlattl, Helmut; Zankl, Maria; Becker, Janine; Petoussi-Henss, Nina; Yeom, Soo Yeon; Kim, Chan Hyeong; Hoeschen, Christoph; Parodi, Katia
In: Physica medica: European journal of medical physics : an international journal devoted to the applications of physics to medicine and biology - Amsterdam: Elsevier, Bd. 39.2017, S. 100-112
Anthropomorphic dual-lattice voxel models for optimizing image quality and dose
Petoussi-Henss, Nina; Schlattl, Helmut; Becker, Janine; Greiter, Matthias; Zankl, Maria; Hoeschen, Christoph
In: Journal of medical imaging - [Bellingham, Wash.]: SPIE, 2014, Bd. 4.2017, 1, Art.-Nr. 013509, insges. 10 S.
Editor
Special section guest editorial - visions of safety : perspectives on radiation exposure and risk in medical imaging
Samei, Ehsan; Hoeschen, Christoph
In: [Bellingham, Wash.]: SPIE, 2017 - (Journal of medical imaging; Vol. 4.2017,3)
2016
Book chapter
Conceptual detector development and Monte Carlo simulation of a novel 3D breast computed tomography system
Ziegle, Jens; Müller, Bernhard H.; Neumann, Bernd; Hoeschen, Christoph
In: Konferenz: SPIE Medical Imaging, 2016, San Diego, California, United States, Proceedings of SPIE/ SPIE - Bellingham, Wash.: SPIE, Bd. 9783 (2016)
Peer-reviewed journal article
Diet-induced and mono-genetic obesity alter volatile organic compound signature in mice
Kistler, Martin; Muntean, Andreea; Szymczak, Wilfried; Rink, Nadine; Fuchs, Helmut; Gailus-Durner, Valerie; Wurst, Wolfgang; Hoeschen, Christoph; Klingenspor, Martin; Hrabě de Angelis, Martin; Rozman, Jan
In: Journal of breath research: volatiles for medical diagnosis : official journal of the International Association for Breath Research (IABR) and the International Society for Breath Odor Research (ISBOR) - Bristol: IOP, Vol. 10.2016, 1, Art. 016009, insgesamt 16 S.
Uncertainty quantification in internal dose calculations for seven selected radiopharmaceuticals
Spielmann, Vladimir; Li, Wei Bo; Zankl, Maria; Oeh, Uwe; Hoeschen, Christoph
In: Journal of nuclear medicine: JNM - New York, NY: Soc, Bd. 57.2016, 1, S. 122-128
Optimisation in x-ray and molecular imaging 2015
Båth, Magnus; Hoeschen, Christoph; Mattsson, Sören; Månsson, Lars Gunnar
In: Radiation protection dosimetry - Ashford: Oxford Univ. Press, 1981, Bd. 169.2016, 1/4, S. 1-439[Konferenz: "This issue is based on contributions to Optimisation in X-ray and Molecular Imaging 2015the 4th Malmö Conference on Medical Imaging (OXMI 2015), which was held from 28 to 30 May 2015 at Sahlgrenska University Hospital/University of Gothenburg in Gothenburg, Sweden.]
Optimisation in X-ray and molecular imaging 2015[Editorial]
Båth, Magnus; Hoeschen, Christoph; Mattsson, Sören; Månsson, Lars Gunnar
In: Radiation protection dosimetry - Ashford: Oxford Univ. Press, Bd. 169.2016, 1/4, S. 1
Effect of blood activity on dosimetric calculations for radiopharmaceuticals
Zvereva, Alexandra; Petoussi-Henss, Nina; Li, Wei Bo; Schlattl, Helmut; Oeh, Uwe; Zankl, Maria; Graner, Frank Philipp; Hoeschen, Christoph; Nekolla, Stephan G.; Parodi, Katia; Schwaiger, Markus
In: Physics in medicine and biology: an official journal of the Institute of Physics and Engineering in Medicine - Bristol: IOP Publ, Bd. 61.2016, 21, S. 7688-7703
Editor
OXMI 2015$proceedings of Optimisation in X-ray and Molecular Imaging 2015 - the 4th Malmö Confeerence on Medical Imaging
Båth, Magnus; Hoeschen, Christoph; Mattsson, Sören; Månsson, Lars Gunnar
In: Oxford Press, 2016, 1 Online-Ressource - (Radiation protection dosimetry; 169,1/4)
2015
Peer-reviewed journal article
Task-based measures of image quality and their relation to radiation dose and patient risk
Barrett, Harrison H.; Myers, Kyle J.; Hoeschen, Christoph; Kupinski, Matthew A.; Little, Mark P.
In: Physics in medicine and biology - Bristol : IOP Publ., Bd. 60 (2015), Heft 2, insges. 76 S.
Simulation on the molecular radiosensitization effect of gold nanoparticles in cells irradiated by x-rays
Xie, W. Z.; Friedland, W.; Li, W. B.; Li, C. Y.; Oeh, U.; Qiu, R.; Li, J. L.; Hoeschen, Christoph
In: Physics in medicine and biology: an official journal of the Institute of Physics and Engineering in Medicine - Bristol: IOP Publ., Vol.60.2016, 16, Art. 6195, insgesamt 19 S., 2015
Feasibility of spectral CT imaging for the detection of liver lesions with gold-based contrast agents - a simulation study
Müllner, Marie; Schlattl, Helmut; Hoeschen, Christoph; Dietrich, Olaf
In: Physica medica - Amsterdam: Elsevier, Bd. 31 (2015), 8, S. 875-881
2014
Peer-reviewed journal article
Developing a physiologically based approach for modeling plutonium decorporation therapy with DTPA
Kastl, Manuel; Giussani, Augusto; Blanchardon, Eric; Breustedt, Bastian; Fritsch, Paul; Hoeschen, Christoph; Lopez, Maria Antonia
In: International journal of radiation biology - London: Taylor & Francis, Bd. 90.2014, 11, S. 1062-1067
Age-dependent inhalation doses to members of the public from indoor short-lived radon progeny
Brudecki, Kamil; Li, Wei Bo; Meisenberg, Oliver; Tschiersch, Jochen; Hoeschen, Christoph; Oeh, Uwe
In: Radiation and environmental biophysics - Berlin: Springer, Bd. 53.2014, 3, S. 535-549
2009
Journal/Series
Only therapeutic ICOS:ICOSL blockade alleviates acute graft versus host disease.
Mollweide, A; Staege, M S; Hoeschen, C; Hideo, Y; Burdach, S; Richter, G H S
In: Klinische Pädiatrie, Vol. 221, 2009, S. 344-50, ISSN 1439-3824, 10.1055/s-0029-1239532
2002
Original article in peer-reviewed national journal
Optimierte Bildverarbeitung durch ein modifiziertes Pre-Processing von Bilddatensätzen eines transparenten Speicherfoliensystems am Beispiel der seitlichen HWS-Aufnahme.
Reissberg, Steffen; Hoeschen, Christoph; Redlich, Ulf; Scherlach, Cordula; Preuss, Heide; Kaestner, Andrea; Woischneck, Dieter; Schuetze, Michael; Reichardt, Kerstin; Firsching, Raimund; Doehring, Wilfried
In: RöFo Fortschr. Geb. Röntgenstr. 174(2002), S. 1296 - 1300
- Kirchoff Institut für Physik, Heidelberg
- Forschungszentrum Jülich
- Nuevo Hospital La Fe, Valencia
- Universitätsklinikum Magdeburg
- Städtisches Klinikum Magdeburg
- Helmholtz Zentrum München
- Bayer AG Radiology
- AGFA Healthcare
- CERN
- Coimbra Health school, Portugal
- CREAL, Barcelona
- EIBIR, Wien
- ETH Zürich
- Eckert & Ziegler Strahlen- und Medizintechnik AG, Berlin - Seed Imaging
- LMU München
- MedAustron
- Uni Erlangen
- Uni Hamburg
- University of Rome "Tor Vergata", Italy, Prof. L. Santo
- HNO Klinik, OvGU, Prof. Christoph Arens
- MHH, Prof. Dr. med. Frank Wacker
- MOXTEK Inc., Salt Lake City, USA
- National Institute of Standards and Technology (NIST)
- Orthopädische Universitätsklinik, Magdeburg
- OVGU Magdeburg, Universitätsklinik für Hals-, Nasen- und Ohrenheilkunde, Kopf- und Halschirurgie (KHNO)
- OVGU Magdeburg, Universitätsklinik für Herz- und Thoraxchirurgie (KCHH)
- OVGU Magdeburg, Universitätsklinik für Strahlentherapie
- OVGU Radiologie, Prof. Fischbach, Prof. Pech
- Siemens Healthcare GmbH
- Universitätsklinikum Magdeburg, Institut für Pathologie
- Bundesamt für Stahlenschutz
- CEA - French Alternative Energies and Atomic Energy Commission
- CESCA-FUNDACION PUBLICA GALLEGA CENTRO TECNOLOGICO DE SUPERCOMPUTACION DE GALICIA
- COCIR - European Coordination Committee of the Radiological, Electromedical and healthcare IT Industry
- DESY, Hamburg
- DKFZ - Deutsches Krebsforschungszentrum
- ECCO - European CanCer Organisation
- Erasmus universitair medisch centrum Rotterdam
- EURAMED - European Alliance for Medical Radiation Protection Research
- European University of Cyprus
- Fondazione Toscana Gabriele Monasterio
- IRSN - Institut de Radioprotection et de Sûreté Nucléaire
- Istituto Giannina Gaslini
- JAN KOCHANOWSKI UNIVERSITY
- Katholische Universität Leuven
- NARODOWE CENTRUM BADAN JADROWYCH
- Nemzeti Népegészségügyi Központ
- NKI - Stichting Het Nederlands Kanker Instituut–Antoni van Leeuwenhoek Ziekenhuis
- QAELUM NV
- Ruder Boškovic Institute
- Sahlgrenska university hospital, Göteborg
- SCK-CEN: Studiecentrum voor Kernenergie
- SERVIZO GALEGO DE SAUDE
- SKANDION - KOMMUNALFORBUNDET AVANCERAD STRALBEHANDLING
- Stockholms Universitet
- STUK - Radiation and Nuclear Safety Authority Finnland
- SWIETOKRZYSKIE CENTRUM ONKOLOGII
- Universitaetsklinikum Freiburg
- Universität Hamburg (Prof. Grüner), Hamburg
- Universität Lübeck
- Universität Mainz, Klinik für Diagnostische und Interventionelle Radioogie
- Universitätsklinik für Psychiatrie und Psychotherapie, OvGU, Prof. Frodl
- Universität Zagreb
- UNIVERSITE DE GENEVE
- UNIVERSITEIT GENT
- Université Paris Descartes
- University Hospital Descartes, Paris
- University Medical Center Ljubljana
- university of crete, Kreta
- University of Dublin
- University of Exeter
- University of Umea
- University Tartu
- VHIO - Fundacio Privada Institut D’Investigacio Oncologica de Vall-Hebron
- Vrije Universiteit Brussels
- Dosimetrie
- medizinischer Strahlenschutz
- Bildgebung mit speziellen Röntgenquellen
- nuklearmedizinische Bildgebung
- biokinetische Modellierung
- Atemluftanalytik
- Medizinphysik
- Medizinphysikberatungen
- Strahlenschutzkommission verschiedenen Funktionen in Ausschuss "Strahlenschutztechnik" und Arbeitsgruppen
- EURAMED (europäische Platform für medizinischen Strahlenschutz) chair
1996-1999 wissenschaftlicher MA, PTB Braunschweig, EU Projekt
1999-2004 wissenschaftlicher MA, Uniklinikum Magdeburg, Radiologie
2002 Promotion Dr. rer. nat. Otto-von-Guericke-Universität Magdeburg
2004-2010 Gruppenleiter "Medizinphysik" Helmholtz Zentrum München (früher GSF)
2007 Behnken-Berger- Preis, 1. Platz
2010-2016 Abteilungsleiter "Medizinische Strahlungsphysik und Diagnostik", Helmholtz Zentrum München
2011-2013 zusätzlich Abteilungsleiter "Auswertestelle Personendosimetrie"
seit 2014 W3 Professor "Medizintechnische Systeme" Institut für Medizintechnik, Fakultät für Elektrotechnik und Informationstechnologie, Otto-von-Guericke Universität Magdeburg
seit Oktober 2016 Prodekan ebenda